This is the sequel to Rob Zombie's House of 1000 Corpses, set some time after the original films plot line it opens with a raid on the murderous Firefly home by Ruggsville County Sheriff John Wydell, brother of Firefly victim Deputy George Wydell (from the first film). After a shootout in which several deputies are killed , with one son killed, Mother Firefly is captured , Baby,and Otis escape and rendezvous later with the Firefly patriarch, the mad clown Capt Spaulding. After a mind blowing murder escapade at a dusty desert motel they retreat to a frontier town whorehouse run by Spaulding's adopted "brother" Charlie, while Sheriff Wydell slowly loses his mind in his quest for revenge. He enlists the help of two equally disgusting bounty hunters and tracks the the trio, now dubbed the "Devil'Rejects" by the media to their location and sets the stage for the final showdown.