A mysterious virus, carried by mutant rats, creates pandemonium in New York City in which rat-bite victims turn into homicidal rat-mutants. This movie centers on six tenants of a tumbledown tenement on Mulberry Street who grouse about the heat; Clutch is a former boxer waiting the arrival of his daughter Casey, a physically and emotionally scared Iraq War veteran; Coco is the resident drag queen, while Kay is a local waitress at odds with her teenage son Otto, whom Clutch acts as a father figure to; Frank is a cancer-stricken World War II veteran hold up in his apartment at odds with the building superintendent Charlie. But as night falls, they find themselves battling a horde of mutants turning powerless New Yorkers into a bloodthirsty new rat/cannibal zombie-like species. Clutch must lead the tenants as they fight to survive the night against the both the rats and the rapidly multiplying cannibal mutants.
